---
title: Identify Genetic Etiologies in Patients w/ Severe Hypertriglyceridemia
description: Arrowhead Pharmaceuticals, Ambry Genetics' no-cost genetic testing program for patients who have a clinical history of severe hypertriglyceridemia.
---

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## Arrowhead Pharmaceuticals

## and Ambry Genetics

**Identifying Genetic Etiologies in Patients with Severe** **Hypertriglyceridemia**

###### **QUESTIONS?**

###### Are you a **healthcare professional** interested in learning more? Fill out the form below to have an Ambry representative contact you.

#### Providing Answers to Patients

Arrowhead Pharmaceuticals is partnering with Ambry Genetics to provide a sponsored genetic testing program for patients who have a clinical history of severe hypertriglyceridemia. Patients who are eligible for this program may have an underlying genetic cause of their complications, such as Familial Chylomicronemia Syndrome or hyperlipoproteinemia. This test can only be ordered by a health care provider.

#### **Why is Genetic Testing Important?**

Elevated triglyceride levels are an independent risk factor for cardiovascular disease, and severely elevated triglycerides may be a sign of a rare genetic disorder Familial Chylomicronemia Syndrome (FCS). For patients and families, genetic testing can lead to an accurate and early diagnosis of FCS, familial hypertriglyceridemia, or hyperlipoproteinemia. Arrowhead Pharmaceuticals is sponsoring genetic testing through Ambry Genetics to help facilitate early diagnosis, which can help optimize disease management.

 

#### **What is FCSNext?**

Ambry Genetics’ FCSNext panel is a 5-gene test aimed at identifying the underlying genetic cause of hypertriglyceridemia in eligible patients. This includes disorders such as Familial Chylomicronemia Syndrome or other clinically associated conditions. Genes included are associated with one or more key clinical symptoms, including: severely high triglyceride levels, acute bouts of pancreatitis, severe abdominal pain, skin xanthomas, brain fog, and milky appearance of the blood/veins.

Establishing an underlying molecular cause is a critical step in providing accurate diagnosis, prognosis, genetic counseling, and disease management.

#### Testing Eligibility

- 17 years of age and older AND
- Fasting triglyceride level of >600 mg/dL in the past 12 months

Testing Exclusions

- Prior genetic testing for FCS
- < 17 years of age

 5-gene panel

APOA5, APOC2, GPIHBP1, LMF1, LPL

#### How The Program Works

![Order A Test](https://info.ambrygenetics.com/hs-fs/hubfs/Group%20294.png?width=60&height=82&name=Group%20294.png "Order A Test")

#### Step 1: Order a Test with a Kit Shipped Directly to Your Patient

To place an order, download [English](https://hubs.ly/Q04xzXh50) or [French Canadian](https://hubs.ly/Q04xFZBc0) and complete the Test Requisition Form (TRF).

Check the box to have a buccal collection kit sent to the patient's address

.

![send-the-completed-trf-to-ambry-icon-updated1](https://info.ambrygenetics.com/hubfs/send-the-completed-trf-to-ambry-icon-updated1.svg "send-the-completed-trf-to-ambry-icon-updated1")

#### Step 2: Send the Completed TRF to Ambry

Send via:

Email: [info@ambrygen.com](mailto:info@ambrygen.com)

Or

FAX: 949.900.5501

.

![Collect](https://info.ambrygenetics.com/hs-fs/hubfs/Group%20292.png?width=60&height=82&name=Group%20292.png "Collect")

#### Step 3: Patient Collects the Buccal Sample

Your patient will receive a buccal sample kit and will be able to submit directly to Ambry for testing.

![Receive](https://info.ambrygenetics.com/hs-fs/hubfs/Group%20293.png?width=60&height=82&name=Group%20293.png "Receive")

#### Step 4: Receive Results

Results are available 2-3 weeks after Ambry receives the sample.

The ordering healthcare provider will receive a notification once the test results are ready.

![](https://info.ambrygenetics.com/hs-fs/hubfs/ah_logo_cmyk-01.png?width=300&height=100&name=ah_logo_cmyk-01.png)

#### Questions? Contact Us

[info@ambrygen.com](mailto:info@ambrygen.com)