Providing Answers at No Cost to Patients
Arrowhead Pharmaceuticals is partnering with Ambry Genetics to provide a sponsored, no-cost genetic testing program for patients who have a clinical history of severe hypertriglyceridemia. Patients who are eligible for this program may have an underlying genetic cause of their complications, such as Familial Chylomicronemia Syndrome or hyperlipoproteinemia.
Why is Genetic Testing Important?
Elevated triglyceride levels are an independent risk factor for cardiovascular disease, and severely elevated triglycerides may be a sign of a rare genetic disorder Familial Chylomicronemia Syndrome (FCS). For patients and families, genetic testing can lead to an accurate and early diagnosis of FCS, familial hypertriglyceridemia, or hyperlipoproteinemia. Arrowhead Pharmaceuticals is sponsoring no-cost genetic testing through Ambry Genetics to help facilitate early diagnosis, which can help optimize disease management.
What is HTG-Select?
Ambry Genetics’ HTG-Select panel is a 6-gene test aimed at identifying the underlying genetic cause of hypertriglyceridemia in eligible patients. This includes disorders such as Familial Chylomicronemia Syndrome or other clinically associated conditions. Genes included are associated with one or more key clinical symptoms, including: severely high triglyceride levels, acute bouts of pancreatitis, severe abdominal pain, skin xanthomas, memory loss, and milky appearance of the blood/veins.
Establishing an underlying molecular cause is a critical step in providing accurate diagnosis, prognosis, genetic counseling, and disease management.
Testing Eligibility
- 17 years of age and older AND
- Fasting triglyceride level of >750 mg/dL [> 8.48 mmol/L] in the past 12 months
Testing Exclusions
- Prior genetic testing for FCS
- < 17 years of age
A custom ordering form will ship with each kit.
APOA5, APOC2, GPD1, GPIHBP1, LMF1, LPL
How The Program Works – Healthcare Provider
Step 1: Order a Test Kit
To place your online order, click here and follow the prompts.
To place a paper-based order, download and complete the Test Requisition Form (TRF). Include it in the specimen box.
Step 2: Collect a Sample
Use the provided Ambry Genetics’ Test Kit to collect the patient’s blood, buccal, or saliva sample after reviewing the specimen and shipping requirements. Submit the kit and completed TRF using the instructions provided in the kit.
Step 3: Receive Results
Results are available 3-5 weeks after Ambry receives the sample. The ordering healthcare provider will receive a notification once the test results are ready.
How The Program Works – Patient Directed Testing
Step 1: Schedule a Consultation
Talk with a certified genetic counselor to review your personal and family health history.
Step 2: Order Test
If you meet eligibility criteria for the program, a test order will be placed by the Genome Medical physician for you at no charge.
Step 3: Receive Results
Results are available 3-5 weeks after Ambry receives the sample. You can review your results with a genetic counselor or medical geneticist free of charge.
